Coffee is also thought to help reduce inflammation, at least in some people.
This article reviews coffee’s effects on inflammation, as well as whether decaffeinated coffee has the same effects.
Contains a complex mixture of active compounds
Regular coffee contains a complex mixture of active compounds, including caffeine, chlorogenic acid (CGA), cafestol, trigonelline, and kahweol. Decaffeinated coffee contains the same compounds, although it contains little to no caffeine (1Trusted Source, 2).
Experts believe that their presence may explain why drinking coffee — whether it’s regular or decaf — is often linked to a lower risk of illnesses, such as type 2 diabetes, heart disease, and possibly even certain types of cancer (1Trusted Source, 3Trusted Source).
Effects on inflammation
Current research suggests that coffee may help reduce inflammation, at least in certain individuals.
In one study, regular coffee drinkers had lower levels of inflammatory markers than non-regular coffee drinkers (4Trusted Source).
In another study, regular coffee drinkers experienced a 6% increase in their inflammatory marker levels when asked to refrain from drinking coffee for 1 month.
In comparison, they experienced an 8–16% reduction in inflammatory markers when asked to consume either 32 or 64 ounces (0.9 or 1.9 liters) of coffee per day for the same time period (5Trusted Source).
What’s more, a review of 15 studies on the effects of coffee, caffeine, and other coffee-related components on inflammatory markers found that low, medium, and high coffee intake has predominantly anti-inflammatory effects (3Trusted Source).
Nevertheless, some evidence suggests that coffee may increase inflammation in some people. Therefore, individual differences in genetics or other factors likely influence coffee’s effect on inflammation (3Trusted Source, 6Trusted Source).
Inflammation can lead to a variety of effects, including frequent infections, fatigue, pain, and digestive problems. If you experience any of these while drinking coffee, consider reducing your intake to see whether doing so helps (7Trusted Source).